While there are so many actors and pop-culture icons who added to the beauty of this show, being a huge Star Trek geek, I have to go with the cast that participated in the episode Where No Fan Has Gone Before
Honorable mention to Bea Arthur as Femputer.
For all things Futurama
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Rule 2: Alternate video links to be linked in a comment, below the original video.
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Gary Gygax.
“It’s a…” rolls dice “Pleasure to meet you!”