Basically more everything. 2x Cortex M33 cores with floating point, 520KB ram, more PIOs, bunch of secure boot stuff (I have mixed feelings about this), and can boot to a mode with risc-v cores instead of the M33s.
Idk about took off but it was a successful product by reasonable standards. I have a few of them and chose it for a product that ended up going nowhere. That was partly because of hardware add-ons available for the pico but not for comparable boards. The existence of that 3rd party hardware ecosystem itself shows that the pico did ok.
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The Pico never really took off, honestly. I doubt this thing is going to fly off the shelves or anything.
Idk about took off but it was a successful product by reasonable standards. I have a few of them and chose it for a product that ended up going nowhere. That was partly because of hardware add-ons available for the pico but not for comparable boards. The existence of that 3rd party hardware ecosystem itself shows that the pico did ok.